Cutaneous arterial and venous alpha receptor blocking activity following intraduodenal indoramin to dogs

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Structured PICO

Population

Canine hindpaw preparation perfused at constant flow

Intervention

Indoramin (5 and 20 mg/kg, intraduodenal)

Comparator

Prazosin (0.25 and 1.0 mg/kg, intraduodenal)

Outcome

Arterial and venous pressor responses to sympathetic nerve stimulation (SNS) and norepinephrine (NE), and mean arterial blood pressure (MAP)surrogate

Indoramin lowers blood pressure in dogs through a mechanism distinct from the typical postsynaptic alpha-1 receptor blockade seen with prazosin.

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Indoramin lowers BP independently of postsynaptic α1-blockade in dogs; leaves open whether this mechanism operates in clinical hypertension.

Greenberg et al. (1990) studied this question.

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Indoramin lowers BP independently of postsynaptic α1-blockade in dogs; leaves open whether this mechanism operates in clinical hypertension.