Why the study?
Do indoramin and prazosin alter arterial pressure and heart rate in normal volunteers?
Population
5 normal volunteers
Comparison
Indoramin 25 mg and prazosin 1 mg, single and… vs Placebo
Design
Other
Follow-up
4 days per study period
Authors
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Acute hemodynamic differences in volunteers should not guide dosing; leaves open comparative effects after repeated use in patients.
Do indoramin and prazosin alter arterial pressure and heart rate in normal volunteers?
Indoramin and prazosin have differing acute effects on standing blood pressure and heart rate in normal subjects, though their effects become similar after repeated administration.
Nicholls et al. (1981) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: