Why the study?
Does indoramin added to a thiazide diuretic reduce blood pressure in patients with inadequately controlled hypertension?
Population
122 hypertensive patients whose blood pressure was inadequately controlled by thiazide diuretic alone.
Design
Cohort, open-label
Follow-up
up to 27 months
Authors
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Supports indoramin add-on hypothesis in resistant hypertension; leaves open need for RCTs to confirm efficacy and safety.
Does indoramin added to a thiazide diuretic reduce blood pressure in patients with inadequately controlled hypertension?
Indoramin effectively reduces blood pressure when added to a thiazide diuretic in patients with inadequately controlled hypertension, though side effects like sedation and dizziness are common.
M Fitzgerald (1981) studied this question.
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