What question did this study set out to answer?

To evaluate the antihypertensive effectiveness and dose-response profile of daily 1 mg versus 2 mg indapamide over a six-week period in mild to moderate essential hypertension.

January 1, 1977Current Medical Research and Opinion

A double-blind multicentre study of indapamide in the treatment of essential hypertension

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Why the study?

Does indapamide 2 mg daily improve blood pressure reduction compared to 1 mg daily in patients with mild to moderate essential hypertension?

Population

101 patients with mild to moderate essential hypertension

Comparison

Indapamide 2 mg daily for 6 weeks vs Indapamide 1 mg daily for 6 weeks

Design

RCT, double-blind

Follow-up

6 weeks

Authors

JHJun HashidaNihon University

Discussion

Member takes

Implication

1 mg indapamide matches 2 mg for BP reduction; confirms equivalent efficacy without added benefit in mild-moderate hypertension.

Key Points

To evaluate the antihypertensive effectiveness and dose-response profile of daily 1 mg versus 2 mg indapamide over a six-week period in mild to moderate essential hypertension.
Conducted a double-blind, multicentre clinical trial in 101 patients diagnosed with mild to moderate essential hypertension.
Assigned patients to receive either 1 mg or 2 mg of indapamide daily over a 6-week treatment duration.
Measured systolic, diastolic, and mean blood pressure at baseline and every two weeks, alongside biochemical monitoring and adverse effect evaluation.
Both 1 mg and 2 mg daily regimens produced significant reductions from baseline in systolic, diastolic, and mean blood pressure (p<0.05), with no statistically significant difference between dose groups despite a faster response trend at 2 mg.
Adverse effects were mild and did not increase in frequency or severity with higher dosing, resulting in only 1 patient withdrawal due to severe palpitations.
Biochemical tests showed minor reductions in serum potassium and chloride alongside slight increases in uric acid and blood urea nitrogen, but all laboratory parameters remained within normal limits.

Structured PICO

Does indapamide 2 mg daily improve blood pressure reduction compared to 1 mg daily in patients with mild to moderate essential hypertension?

Population

101 patients with mild to moderate essential hypertension

Intervention

Indapamide 2 mg daily for 6 weeks

Comparator

Indapamide 1 mg daily for 6 weeks

Outcome

Reduction in systolic, diastolic and mean blood pressure at 6 weekssurrogate

Indapamide at both 1 mg and 2 mg daily effectively reduces blood pressure in mild to moderate essential hypertension, with the 1 mg dose offering similar efficacy to the 2 mg dose.

Cite This Study

Jun Hashida (1977) studied this question.

synapsesocial.com/papers/6a77a02b6789de8d0af75402 https://doi.org/10.1185/03007997709110232

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Ask AI

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A double-blind multicentre study of indapamide in the treatment of essential hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

A double-blind multicentre study of indapamide in the treatment of essential hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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