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Randomized double-blind crossover trial shows indapamide matches Moduretic in lowering blood pressure in hypertensive patients, indicating comparable efficacy without major adverse effects.
A randomized double-blind, crossover trial was carried out in twenty hypertensive patients to evaluate the hypotensive efficacy and safety of indapamide. Indapamide in doses of 2.5 mg per day in combination with other antihypertensive agents was as effective in reducing the blood pressure in hypertensive patients as one tablet of Moduretic (50 mg hydrochlorothiazide and 5 mg amiloride). Indapamide induced no changes in serum potassium or uric acid levels and there were no major side effects.
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Anavekar et al. (1979) studied this question.
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