Why the study?
Does indapamide reduce blood pressure compared to hydrochlorothiazide in patients with mild hypertension?
Population
24 patients with mild essential arterial hypertension
Comparison
Indapamide 2.5 mg per day for 12 weeks vs Hydrochlorothiazide 50 mg per day for 12 weeks
Design
RCT, double-blind
Follow-up
12 weeks
Authors
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Indapamide offers consistent diastolic BP reduction in mild hypertension; extends RCT evidence favoring it over hydrochlorothiazide for position-independent control.
Does indapamide reduce blood pressure compared to hydrochlorothiazide in patients with mild hypertension?
Indapamide 2.5 mg daily effectively reduces both upright and recumbent diastolic blood pressure in mild hypertension, with a favorable tolerability profile compared to hydrochlorothiazide.
Plante et al. (1983) studied this question.
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