Why the study?
Does low-dose indapamide (0.5-1.0 mg daily) normalize blood pressure in ambulatory patients with mild essential hypertension?
Population
13 ambulatory patients with mild essential hypertension (diastolic blood pressure 90 to 114 mmHg)
Comparison
Indapamide 0.5 mg daily for 6 weeks, increased… vs 30-day placebo run-in period
Design
Cohort
Follow-up
12 weeks
Authors
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Low-dose indapamide rarely normalized BP in this cohort; leaves open whether titration or alternatives are needed in mild hypertension.
Does low-dose indapamide (0.5-1.0 mg daily) normalize blood pressure in ambulatory patients with mild essential hypertension?
Low doses of indapamide (0.5-1.0 mg daily) are insufficient to normalize blood pressure in most patients with mild essential hypertension.
Fernandes et al. (1977) studied this question.
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