Why the study?
Does indapamide reduce blood pressure differently than hydrochlorothiazide in patients with uncomplicated essential hypertension?
Population
17 patients (11 males) aged 34-66 years with uncomplicated essential hypertension
Comparison
Indapamide 2.5 mg once daily in the morning for… vs Hydrochlorothiazide 50 mg once daily in the…
Design
RCT, randomized, double-blind, placebo-controlled
Follow-up
3 months per active drug phase
Authors
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Supports interchangeable use of either agent; confirms equivalent efficacy in uncomplicated essential hypertension.
Does indapamide reduce blood pressure differently than hydrochlorothiazide in patients with uncomplicated essential hypertension?
Indapamide 2.5 mg and hydrochlorothiazide 50 mg are equally effective in lowering blood pressure and have similar metabolic effects in patients with essential hypertension.
Kreeft et al. (1984) studied this question.
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