Key result
Indoramin 10 mg/kg administered prior to coronary ligation in rats significantly reduced the risk of death and ventricular fibrillation compared with placebo (p < 0.05).
Population
Preclinical models: isolated guinea pig atria, isolated perfused electrically driven guinea pig hearts…
Comparison
Indoramin vs Mexiletine, sotalol, prazosin, and placebo
Design
Preclinical
Authors
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Indoramin's protective effects in rat ischemia are hypothesis-generating; clinical translation remains untested and should not change practice.
p-value: p=<0.05
Indoramin demonstrates both class I and class III antiarrhythmic properties and protects against ventricular fibrillation and death in preclinical ischemia models.
D. W. G. Harron (1986) studied Arrhythmia (experimental models). Indoramin vs. Mexiletine, sotalol, prazosin, and placebo was evaluated on Risk of death (incidence of death and ventricular fibrillation as well as duration of VF) (p=<0.05). Indoramin 10 mg/kg administered prior to coronary ligation in rats significantly reduced the risk of death and ventricular fibrillation compared with placebo (p < 0.05).
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