Why the study?
Does indoramin 100 mg affect ECG time intervals in normal human subjects?
Does indoramin 100 mg affect ECG time intervals in normal human subjects?
Indoramin prolongs QTc without changing QRS duration, suggesting potential Class III antiarrhythmic activity that may explain its lack of reflex tachycardia.
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Caution advised with indoramin 100 mg due to QTc effects; leaves open antiarrhythmic utility pending patient data.
The effect of indoramin, a selective alpha 1-adrenoceptor antagonist, on ECG time intervals in normal man was studied. Significant prolongation of QTc was observed after indoramin 100 mg, with no change in QRS duration. In addition, the slope of the RR/QT relationship was changed by indoramin 100 mg. These results suggest that indoramin may have Class III antiarrhythmic activity. If such activity were to affect the SA node, it may explain at least in part the observed lack of reflex tachycardia after indoramin administration.
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Harron et al. (1985) studied this question.
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