Why the study?
Does indoramin reduce arterial pressure with less reflex sympathetic activation compared to phenoxybenzamine and hydralazine in normal volunteers?
Population
6 normal volunteers
Comparison
Single oral dose of indoramin, phenoxybenzamine… vs Placebo
Design
Other
Follow-up
4 hours
Authors
Loading...
May attenuate reflex HR and NA rises during BP reduction versus comparators in volunteers; leaves open clinical translation of selective α1-blockade.
Does indoramin reduce arterial pressure with less reflex sympathetic activation compared to phenoxybenzamine and hydralazine in normal volunteers?
Indoramin produces selective postsynaptic alpha 1-adrenoceptor blockade, resulting in less reflex tachycardia and noradrenaline increase compared to non-selective alpha-blockers or arteriolar vasodilators.
Nicholls et al. (1984) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: