Key result
Four weeks of propranolol treatment significantly reduced plasma renin activity after tilt from 248.7 to 39.0 ng/100 ml/h (p<0.005) and diastolic blood pressure by 19 mmHg (p<0.001).
Why the study?
Does propranolol reduce plasma renin activity and blood pressure in male patients with mild to moderate essential hypertension?
Population
14 male patients with mild to moderate essential hypertension
Comparison
Propranolol vs Baseline measurements after four weeks of…
Design
Cohort
Follow-up
4 weeks
Authors
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Propranolol was associated with reduced renin activity and BP in mild hypertension; leaves open mechanisms and need for randomized trials.
Does propranolol reduce plasma renin activity and blood pressure in male patients with mild to moderate essential hypertension?
Absolute Event Rate: 39% vs 248.7%
p-value: p=< 0.005
Propranolol significantly reduces both plasma renin activity and blood pressure in patients with mild to moderate essential hypertension, although the reductions are not significantly correlated.
Hansson et al. (1974) studied mild to moderate essential hypertension (n=14). Propranolol vs. Placebo/Baseline was evaluated on Plasma renin activity (PRA) after 10 min of 45° head-up tilt (p=< 0.005). Four weeks of propranolol treatment significantly reduced plasma renin activity after tilt from 248.7 to 39.0 ng/100 ml/h (p<0.005) and diastolic blood pressure by 19 mmHg (p<0.001).
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