Why the study?
Does oral propranolol lower blood pressure and suppress plasma renin activity in patients with mild or moderate essential hypertension?
Does oral propranolol lower blood pressure and suppress plasma renin activity in patients with mild or moderate essential hypertension?
In patients with mild to moderate hypertension, the blood pressure-lowering effect of propranolol is not primarily driven by the suppression of plasma renin activity.
Answers are grounded in this paper and cite their sources.
Questions renin suppression as main driver of propranolol BP lowering; leaves open alternative mechanisms in mild-moderate hypertension.
In patients with mild or moderate essential hypertension, oral propranolol, given in incremental doses, produced a moderate but significant lowering of blood pressure which was correlated with the concentration of propranolol in plasma. 2. Propranolol also reduced plasma renin activity (PRA) in the supine posture, on standing and after intravenous frusemide. However, 'supine' and 'frusemide' PRA values were markedly reduced at a plasma concentration of propranolol that had little effect on blood pressure. 3. On administration of propranolol there was little correlation between blood pressure decrease and PRA suppression, and even less between pretreatment PRA values and hypotensive response. 4. It is concluded that in patients with mild and moderate hypertension and low or normal plasma renin activity, suppression of PRA is not an important determinant of the hypotensive response to propranolol.
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Leonetti et al. (1975) studied this question.
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