Key result
Propranolol treatment reduced plasma renin activity but did not transform primary hypertensive patients into low renin hypertensives specifically sensitive to diuretic treatment.
Why the study?
Does propranolol suppress plasma renin activity during diuretic treatment and cause additional blood pressure fall in primary hypertensive patients?
Population
19 primary hypertensive patients
Comparison
Diuretic, propranolol, and the combination of… vs Active comparators
Design
RCT, random succession
Follow-up
long term
Authors
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These Level 5 observations should not guide therapy; they leave open whether PRA profiling aids antihypertensive selection.
RCT (n=19)
random succession
Does propranolol suppress plasma renin activity during diuretic treatment and cause additional blood pressure fall in primary hypertensive patients?
Propranolol treatment does not transform primary hypertensive patients into 'low renin hypertensives' who are specifically sensitive to diuretic treatment.
Nielsen et al. (1977) conducted an RCT in primary hypertension (n=19). Propranolol and diuretic vs. Diuretic alone, propranolol alone, and combination was evaluated on Plasma renin activity (PRA) and blood pressure reduction. Propranolol treatment reduced plasma renin activity but did not transform primary hypertensive patients into low renin hypertensives specifically sensitive to diuretic treatment.
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