June 1, 1975Circulation Research

Effect of salt depletion and propranolol on blood pressure and plasma renin activity in various forms of hypertension.

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Why the study?

Does the addition of propranolol to diuretic therapy reduce blood pressure and plasma renin activity in patients with various forms of hypertension?

Population

38 patients with various forms of hypertension, including essential hypertension, renal artery stenosis, and…

Comparison

Propranolol added to salt depletion/diuretic… vs Baseline values.

Design

Cohort

Follow-up

Up to 2 months

Authors

GGG. G. GeyskesHypertension Institute PBPeter de BoerRadiotherapeutisch Instituut Friesland JVJ VosBarts Health NHS Trust

Discussion

Member takes

Implication

Supports combining propranolol with diuretics for BP control independent of renin; leaves open randomized confirmation in hypertension.

Structured PICO

Does the addition of propranolol to diuretic therapy reduce blood pressure and plasma renin activity in patients with various forms of hypertension?

Population

38 patients with various forms of hypertension, including essential hypertension (n=28), renal artery stenosis (n=5), and moderate renal failure (n=5).

Intervention

Propranolol (e.g., 640 mg daily in Group A) added to salt depletion/diuretic therapy (e.g., chlorthalidone, furosemide).

Comparator

Baseline values (patients on diuretic therapy/salt depletion alone prior to propranolol addition).

Outcome

Change in mean arterial pressure (MAP) and plasma renin activity (PRA).surrogate

The combination of diuretics and propranolol effectively lowers blood pressure in various forms of hypertension, independent of baseline plasma renin activity.

Cite This Study

Geyskes et al. (1975) studied this question.

synapsesocial.com/papers/6a8c6ced337b601d38d77199 https://doi.org/10.1161/01.res.36.6.248

Topics

Hypertension management

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