Key result
Short-term plasma renin activity response to salt depletion and propranolol predicted long-term PRA levels (r=0.02) but was of no value in predicting diastolic blood pressure reduction.
Why the study?
Does short-term plasma renin activity response to salt depletion and propranolol predict long-term PRA levels and blood pressure reduction in patients with benign primary hypertension?
Population
19 patients with benign primary hypertension
Comparison
Short-term salt depletion and bolus injection of… vs Long-term treatment with diuretic and with…
Design
Cohort
Authors
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Short-term PRA testing may predict long-term responses to diuretics or propranolol; leaves open clinical utility in primary hypertension.
Observational (n=19)
Does short-term plasma renin activity response to salt depletion and propranolol predict long-term PRA levels and blood pressure reduction in patients with benign primary hypertension?
Effect estimate: r=0.02
Short-term plasma renin activity response to salt depletion or propranolol predicts long-term PRA levels but is not useful for predicting long-term blood pressure reduction in primary hypertension.
Nielsen et al. (1978) conducted an observational in Benign primary hypertension (n=19). Short-term salt depletion and propranolol vs. Long-term treatment with diuretic and propranolol was evaluated on Correlation between plasma renin activity (PRA) during short-term and long-term treatment, and relation to diastolic blood pressure reduction (r=0.02). Short-term plasma renin activity response to salt depletion and propranolol predicted long-term PRA levels (r=0.02) but was of no value in predicting diastolic blood pressure reduction.
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