Why the study?
Does propranolol alter systemic and renal haemodynamic responses to hyperosmotic saline in patients with essential hypertension?
Population
10 patients with essential hypertension
Comparison
Intravenous load of hyperosmotic saline during… vs Intravenous load of hyperosmotic saline before…
Authors
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Beta-blockade may blunt cardiac and natriuretic responses to volume loading in hypertension; leaves open effects on long-term fluid balance.
Does propranolol alter systemic and renal haemodynamic responses to hyperosmotic saline in patients with essential hypertension?
Chronic beta-blockade with propranolol blunts the cardiac output response to hyperosmotic saline in hypertensive patients, likely due to reduced venous return rather than myocardial depression.
Krauss et al. (1972) studied this question.
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