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November 1, 1982Journal of Cardiovascular Pharmacology

Antihypertensive Effect of Propranolol in Conscious Spontaneously Hypertensive Rats

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Why the study?

Does propranolol alter central hemodynamics, plasma volume, and renal function in conscious spontaneously hypertensive rats?

Population

Conscious spontaneously hypertensive rats (SHR)

Comparison

Propranolol vs Control values (baseline)

Design

Preclinical

Follow-up

5 days

Authors

JSJos F.M. SmitsMACOM (United States)TCT. G. ColemanUniversity of MississippiTSThomas L. SmithWake Forest University

Discussion

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Implication

May guide mechanistic studies of beta-blockade in hypertension models; leaves open translation to human therapy.

Structured PICO

Does propranolol alter central hemodynamics, plasma volume, and renal function in conscious spontaneously hypertensive rats?

P
Population
Conscious spontaneously hypertensive rats (SHR)
I
Intervention
Propranolol (acute injection of 1 and 5 mg/kg, and 5-day infusion of 5 mg/kg/day)
C
Comparator
Control values (baseline)
O
Outcome
Central hemodynamics (heart rate, cardiac output, total peripheral resistance, mean arterial pressure), plasma volume, and renal function (water and sodium excretion, glomerular filtration rate, effective renal plasma flow)surrogate

Propranolol lowers blood pressure in spontaneously hypertensive rats and induces natriuresis, suggesting that tubular beta-receptor blockade may contribute to its long-term antihypertensive efficacy by preventing fluid retention.

Cite This Study

Smits et al. (1982) studied this question.

synapsesocial.com/papers/6a86ae2e6fbb37794f7cab1dhttps://doi.org/10.1097/00005344-198211000-00005

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Role of the Baroreceptor Reflex in the Cardiovascular Effects of Propranolol in the Conscious Spontaneously Hypertensive Rat1979 · 37 citations
  2. 2Chronic propranolol treatment inhibits sympathetic nerve activity and keeps blood pressure from rising in spontaneously hypertensive rats.1980 · 31 citations
  3. 3Mechanism of Increased Sodium Reabsorption during Propranolol Administration1971 · 85 citations
  4. 4Blockade of cardiac and renal beta-receptors by low dose propranolol in normal subjects. Clues to its antihypertensive effect.1979 · 6 citations
  5. 5Immediate Hemodynamic Effects of Beta-Adrenergic Blockade with Propranolol in Normotensive and Hypertensive Man1968 · 178 citations