Why the study?
Does propranolol 80 mg/day reduce blood pressure differently after 1 day versus 2 weeks in patients with normal-renin mild to moderate hypertension?
Does propranolol 80 mg/day reduce blood pressure differently after 1 day versus 2 weeks in patients with normal-renin mild to moderate hypertension?
Low-dose propranolol therapy induces a rapid decrease in systolic blood pressure but a delayed fall in diastolic blood pressure, despite a constant degree of beta-blockade.
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Supports differential systolic-diastolic BP timing with propranolol; leaves open mechanistic and outcome implications in mild-moderate hypertension.
Leenen et al. (1984) studied this question.
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