Why the study?
Does modafinil administration cause systemic and cardiac adverse events in a patient with multiple sclerosis?
Does modafinil administration cause systemic and cardiac adverse events in a patient with multiple sclerosis?
This case highlights a severe adverse reaction, including cardiac involvement (myopericarditis/hypersensitivity), following modafinil use.
May signal rare modafinil cardiac hypersensitivity in MS; single case leaves causality open for confirmation.
A 31-year-old woman was admitted to this hospital because of rash, fever, and facial swelling that developed after the administration of modafinil for the treatment of fatigue associated with multiple sclerosis. Several hours after admission, chest discomfort and hypotension developed, ST-segment elevation was present on the electrocardiogram, and biomarkers of cardiac necrosis were elevated. Echocardiography disclosed a pericardial effusion and left ventricular dysfunction. A diagnostic procedure was performed.
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Sabatine et al. (2007) studied this question.
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