Why the study?
Does altering arterial CO2 oscillation change respiratory center output in anesthetized dogs?
Population
10 anesthetized paralyzed dogs on fixed mechanical ventilation
Comparison
Veno-venous bypass using a membrane lung with… vs Baseline/control state
Design
Preclinical
Authors
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CO2 oscillations unlikely to drive respiratory output in anesthetized models; leaves open their role in awake or human ventilatory control.
Does altering arterial CO2 oscillation change respiratory center output in anesthetized dogs?
Arterial CO2 oscillation appears to play little role in the control of respiration during mild increases in CO2 output in an anesthetized dog model.
Takahashi et al. (1989) studied this question.
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