Key result
Increasing the volume of venous return and infused CO2 together in cats reproduced respiratory responses seen in muscular exercise or other hypermetabolic states.
The study demonstrates that respiratory responses to CO2 are similar whether infused or inhaled, provided venous return is constant, and that changes in venous return interact with CO2 levels to stimulate ventilation.
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Animal data on venous return-CO2 interaction extend exercise hyperpnea models; leaves open human translation and clinical relevance.
Ponte et al. (1978) studied this question. Changes in CO2 infused, volume of venous return, or inhaled CO2 was evaluated on Respiratory responses. Increasing the volume of venous return and infused CO2 together in cats reproduced respiratory responses seen in muscular exercise or other hypermetabolic states.
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