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November 1, 1974Acta Physiologica Scandinavica

Transient and Steady State Effects of C02 on Mechanisms Determining Rate and Depth of Breathing

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Why the study?

Do step changes in inspired CO2 affect tidal volume and respiratory timing in cats?

Population

Cats under light pentobarbitone anesthesia or after decerebration before and after vagotomy

Comparison

Step changes in inspired CO2 vs Baseline/steady state CO2 levels

Design

Preclinical

Authors

GBG. W. BradleyUniversity of LouisvilleCECurt von EulerCentral Michigan UniversityIMIrja MarttilaKarolinska Institutet

Discussion

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Implication

Animal findings in cats should not change practice; hypothesis-generating for distinct CO2 dynamics in respiratory depth versus timing control.

Structured PICO

Do step changes in inspired CO2 affect tidal volume and respiratory timing in cats?

P
Population
Cats under light pentobarbitone anesthesia or after decerebration before and after vagotomy
I
Intervention
Step changes in inspired CO2
C
Comparator
Baseline/steady state CO2 levels
O
Outcome
Changes in tidal volume (VT), inspiratory duration (Ti), and expiratory duration (TE)surrogate

The controller of depth and rate of breathing contains functional components with slightly different dynamic features in response to CO2, which can be disturbed by pentobarbitone.

Cite This Study

Bradley et al. (1974) studied this question.

synapsesocial.com/papers/6a7bf0081f8f1eb7b8ed4483https://doi.org/10.1111/j.1748-1716.1974.tb05752.x
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Respiratory periodicity in the paralyzed, vagotomized cat: hypocapnic polypnea1964 · 77 citations
  2. 2On the regulation of depth and rate of breathing1972 · 717 citations