Key result
Vagal blockade by DC current in anaesthetized rabbits resulted in greater changes in inspiratory tidal volume, inspiratory and expiratory durations, and mean inspiratory flow rate during transient hypercapnia compared to the control state.
Population
Rabbits anaesthetized with ethyl-carbamate
Comparison
Vagal blockade by DC current during transient… vs Control state during transient hypercapnia
Design
Preclinical
Authors
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Indicates vagal-chemoreceptor interaction in ventilatory control; hypothesis-generating and should not change clinical practice.
Vagal blockade enhances the ventilatory response to transient hypercapnia in anaesthetized rabbits, indicating an interaction between vagal and chemoreceptor afferents.
Delpierre et al. (1977) studied this question. Vagal blockade by DC current vs. Control state (before vagal blockade) was evaluated on Ventilatory response (changes in inspiratory tidal volume, inspiratory and expiratory durations, mean inspiratory flow rate, and respiratory frequency) to transient hypercapnia. Vagal blockade by DC current in anaesthetized rabbits resulted in greater changes in inspiratory tidal volume, inspiratory and expiratory durations, and mean inspiratory flow rate during transient hypercapnia compared to the control state.
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