Why the study?
Does external dead space breathing compared to CO2 inhalation alter ventilatory response in human subjects?
Population
Human subjects
Comparison
External dead space (tube) breathing vs CO2 inhalation
Design
Other
Authors
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Dead space breathing may augment hypoxic CO2 response via peripheral chemoreceptors; leaves open mechanistic confirmation and clinical relevance.
Does external dead space breathing compared to CO2 inhalation alter ventilatory response in human subjects?
Augmented ventilatory response to CO2 during dead space breathing compared to CO2 inhalation appears to occur under conditions of peripheral chemoreceptor activation.
Maruyama et al. (1988) studied this question.
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