Red‐Shifted Water‐Soluble BODIPY Photocages for Visualisation and Controllable Cellular Delivery of Signaling Lipids

This is the authors' abstract. We don't add key points for this paper.

In this work, we developed a water‐soluble caging group based on a π‐extended BODIPY scaffold able to release carboxylate‐containing cargo upon red light illumination ( λ irr =633 nm). We performed mechanistic studies showing new insights into the principles of the photoreactivity of these cages and demonstrated a significant influence of the structure of a carboxylate cargo on the rate and efficiency of the uncaging process and its side reactions. We used it for selective delivery, visualisation, and photorelease of a signaling lipid in cell plasma and internal membranes. With this approach, we successfully induced Ca 2+ release in cells expressing the GPR40 receptor.