Effects of intrinsic prostaglandins on the spontaneous contractile and electrical activity of the proximal renal pelvis of the guinea‐pig

View Full Paper

Ask AI

Bookmark

Population

Smooth muscle strips of the guinea-pig renal pelvis

Comparison

Indomethacin and dinoprost vs Baseline (pre-indomethacin) conditions

Design

Preclinical

Authors

Discussion

Hypothesis-generating for prostaglandin role in renal pelvis motility; leaves open translation to human ureteral function or therapy.

Population

Smooth muscle strips of the guinea-pig renal pelvis

Intervention

Indomethacin (1 nM-30 microM) and dinoprost (1 nM-3 microM)

Comparator

Baseline (pre-indomethacin) conditions

Outcome

Spontaneous electrical and contractile activity (amplitude and frequency of contractions and action potentials)surrogate

Endogenous release of prostaglandins is necessary for the in vitro spontaneous contractile and electrical activity in the guinea-pig renal pelvis.

Zhang et al. (1994) studied this question.

View Full Paper

Ask AI

Bookmark