Why the study?
Does indomethacin inhibit smooth muscle contraction and calcium uptake in guinea-pig stomach and aorta?
Population
Guinea-pig stomach muscle strips and aorta
Comparison
Indomethacin (2-20 mg/100 ml or 50 mg/100 ml) vs Control (no indomethacin)
Design
Preclinical
Authors
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Supports calcium uptake inhibition as indomethacin mechanism in animal smooth muscle; leaves open human relevance and clinical translation.
Does indomethacin inhibit smooth muscle contraction and calcium uptake in guinea-pig stomach and aorta?
Indomethacin inhibits smooth muscle contraction by reducing calcium uptake rather than altering ATP or CP content.
B. J. Northover (1971) studied this question.
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