Population
tissue angiotensin-converting enzyme knockout (tisACE-/-) mouse model and wild-type mice
Comparison
tissue angiotensin-converting enzyme knockout vs wild-type mice
Design
Preclinical
Authors
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Tissue ACE deletion lowers intrarenal angiotensin II and BP in mice; hypothesis-generating for selective inhibition in human hypertension.
Tissue ACE depletion significantly reduces intrarenal angiotensin II and I levels while preserving angiotensin-(1-7), which may contribute to chronic hypotension and polyuria.
Modrall et al. (2004) studied this question.
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