May 1, 2004Annals of the New York Academy of SciencesOpen Access

Modeling the Actions of β‐Adrenergic Signaling on Excitation—Contraction Coupling Processes

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Population

Computational model of a canine ventricular myocyte

Comparison

Simulated beta-adrenergic (beta-AR) stimulation vs Baseline model without beta-AR stimulation

Design

Preclinical

Authors

JGJoseph L. GreensteinUniversity of Maryland, Baltimore ATAntti TanskanenRoche (Switzerland)RWRaimond L. WinslowElectrophysiology

Discussion

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Implication

Hypothesis-generating for mode 2 L-type Ca channel gating in EADs; leaves open translation from canine models to clinical arrhythmia risk.

Structured PICO

Population

Computational model of a canine ventricular myocyte

Intervention

Simulated beta-adrenergic (beta-AR) stimulation

Comparator

Baseline model without beta-AR stimulation

Outcome

Changes in action potential (AP), Ca(2+) transients, and excitation-contraction (EC) coupling gainsurrogate

A computational model of canine ventricular myocytes successfully reproduces the effects of beta-adrenergic stimulation on excitation-contraction coupling and predicts mechanisms for early after-depolarizations.

Cite This Study

Greenstein et al. (2004) studied this question.

synapsesocial.com/papers/6a7085992163a0a01bc4bcd2 https://doi.org/10.1196/annals.1302.002

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Implication

Hypothesis-generating for mode 2 L-type Ca channel gating in EADs; leaves open translation from canine models to clinical arrhythmia risk.

Modeling the Actions of β‐Adrenergic Signaling on Excitation—Contraction Coupling Processes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Modeling the Actions of β‐Adrenergic Signaling on Excitation—Contraction Coupling Processes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider