Population
Cardiac ventricular myocytes (preclinical models)
Design
Review
Authors
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May inform selective beta-AR modulation in HF; leaves open validation of microdomain compartmentalization in clinical outcomes.
The coupling of beta-2 adrenergic receptors to Gi proteins and subsequent compartmentalization of signaling provides new insights into cardiac regulation in health and disease.
Xiao et al. (1999) studied this question.
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