The coupling of beta2-adrenergic receptors to Gi proteins is a key factor causing the compartmentalization of beta2-AR-induced cAMP signaling in cardiomyocytes.
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Gi coupling may restrict beta2-AR relaxant effects in cardiomyocytes; leaves open whether Gi inhibition improves cardiac relaxation in vivo or disease.
Kuschel et al. (1999) studied this question.
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