Key result
Stimulation of beta2-adrenergic and other Gs-coupled receptors in human atrial membranes activates Galphai, and disrupting this coupling increases receptor-mediated adenylyl cyclase activity.
Why the study?
Do beta2-adrenergic and other Gs-coupled receptors in human atrial membranes also couple to Gi?
Do beta2-adrenergic and other Gs-coupled receptors in human atrial membranes also couple to Gi?
Beta2-adrenergic and several other Gs-coupled receptors in the human atrium also couple to Gi, which limits their adenylyl cyclase stimulation.
No takes yet. Share an insight, caveat, or question.
No immediate change to atrial arrhythmia care; extends Gs/Gi dual coupling to human atrial receptors.
Kilts et al. (2000) studied Human atrial membranes. Stimulation of beta2-adrenergic and other Gs-coupled receptors was evaluated on Activation of Galpha(i). Stimulation of beta2-adrenergic and other Gs-coupled receptors in human atrial membranes activates Galphai, and disrupting this coupling increases receptor-mediated adenylyl cyclase activity.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: