June 1, 1996Biochemical JournalOpen Access

Binding of a protein to an AU-rich domain of tumour necrosis factor α mRNA as a 35 kDa complex and its regulation in primary rat astrocytes

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Structured PICO

Population

primary rat astrocytes

Intervention

Newcastle disease virus (NDV) infection and phosphatase treatments (alkaline phosphatase, protein phosphatase 1 or 2A)

Outcome

Protein binding to TNF alpha AU-rich domain (ARD) and mobility of ARD-protein complexessurrogate

Demonstrates that a <35 kDa protein binds to the TNF alpha mRNA AU-rich domain in primary rat astrocytes, with its cytoplasmic binding activity regulated post-transcriptionally by phosphorylation.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Hypothesis-generating for TNF-α mRNA regulation in astrocytes; leaves open its role in viral neuroinflammation.

Cite This Study

Kim et al. (1996) studied this question.

synapsesocial.com/papers/6a7086085d37378ac1dda3d3 https://doi.org/10.1042/bj3160455

View Full Paper

Ask AI

Bookmark

Binding of a protein to an AU-rich domain of tumour necrosis factor α mRNA as a 35 kDa complex and its regulation in primary rat astrocytes

Structured PICO

Discussion

Implication

Cite This Study

Binding of a protein to an AU-rich domain of tumour necrosis factor α mRNA as a 35 kDa complex and its regulation in primary rat astrocytes

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider