February 1, 1992Journal of Biological ChemistryOpen Access

Poly(A) removal is the kinase-regulated step in tumor necrosis factor mRNA decay.

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Population

Macrophage-like cell line RAW 264.7 and astrocytes stimulated by virus or lipopolysaccharide

Design

Preclinical

Authors

ALAndrew P. LiebermanUniversity of Michigan PPPaula M. PithaRutgers, The State University of New Jersey MSM L ShinPohang University of Science and Technology

Discussion

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Implication

Should not change clinical practice; leaves open PKC inhibition as a post-transcriptional TNF regulator for further study.

Structured PICO

Population

Macrophage-like cell line RAW 264.7 and astrocytes stimulated by virus or lipopolysaccharide

Intervention

Inhibition of protein kinase C

Outcome

Rate of poly(A) removal from TNF mRNA and TNF mRNA half-lifesurrogate

Inhibition of protein kinase C accelerates TNF mRNA degradation by enhancing poly(A) removal, highlighting a post-transcriptional regulatory mechanism for TNF production.

Cite This Study

Lieberman et al. (1992) studied this question.

synapsesocial.com/papers/6a7bfdc3eac460320975d703 https://doi.org/10.1016/s0021-9258(18)45850-4

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Poly(A) removal is the kinase-regulated step in tumor necrosis factor mRNA decay.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Poly(A) removal is the kinase-regulated step in tumor necrosis factor mRNA decay.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider