Key result
Computational framework proposes a posttranscriptional TTP-TNF feedback loop regulates TNF homeostasis.
Population
Computational model of TTP-TNF interaction loop and TTP knock-out mice
Design
Preclinical
Authors
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Hypothesis-generating for TTP-TNF feedback in inflammation; leaves open its relevance to human disease pending validation.
This computational model provides a framework for understanding the posttranscriptional regulation of TNF homeostasis by TTP during basal and inflammatory conditions.
Aslam et al. (2010) studied Inflammatory bowel disease. TTP-TNF interaction loop was evaluated on TNF biosynthesis response. A computational framework proposes that TNF homeostasis is regulated by a posttranscriptional TTP-TNF interaction loop composed of positive and negative feedback mechanisms.
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