Population
TIA-1-/-, TTP-/-, and TIA-1-/-TTP-/- mice and derived macrophages/neutrophils
Design
Preclinical
Authors
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Neutrophil-derived TNF-alpha may drive erosive arthritis in this model; leaves open therapeutic relevance for human disease.
TIA-1 and TTP function as arthritis-suppressor genes, with their combined absence leading to very severe erosive arthritis likely driven by neutrophil-derived TNF-alpha.
Anderson et al. (2004) studied this question.
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