Impact of Sex on Cardiovascular Outcome in Patients at High Cardiovascular Risk
Why the study?
Does female sex reduce the risk of cardiovascular events compared to male sex in patients with vascular disease or high-risk diabetes mellitus?
Population
31,546 patients with vascular disease or high-risk diabetes mellitus from the ONTARGET and TRANSCEND trials
Comparison
Female sex vs Male sex
Design
Cohort
Follow-up
median, 56 months
Authors
Discussion
Loading...
Member takes
Implication
Women with vascular disease or high-risk diabetes may have lower event rates; leaves open whether sex-specific risk models improve outcomes.
Structured PICO
Does female sex reduce the risk of cardiovascular events compared to male sex in patients with vascular disease or high-risk diabetes mellitus?
P
Population
31,546 patients (9,378 female, 22,168 male) with vascular disease or high-risk diabetes mellitus from the ONTARGET and TRANSCEND trials
I
Intervention
Female sex
C
Comparator
Male sex
O
Outcome
Composite of cardiovascular death, myocardial infarction, stroke, or admission to hospital for heart failurecomposite
In patients with vascular disease or high-risk diabetes, women have a significantly lower risk of major cardiovascular events compared to men, primarily driven by fewer myocardial infarctions.
Cite This Study
Kappert et al. (2012) studied this question.