Why the study?
Can a multiscale computational model predict drug-induced arrhythmias such as torsades de pointes based on single cell electrophysiology?
Population
High-resolution, multiscale computational model of the heart using single cell electrophysiology data
Comparison
Simulated drug-specific current block for… vs Baseline (no drug simulation)
Design
Preclinical
Authors
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Offers rapid in silico cardiotoxicity screening; leaves open clinical translation pending experimental validation.
Can a multiscale computational model predict drug-induced arrhythmias such as torsades de pointes based on single cell electrophysiology?
A multiscale computational model successfully predicted the arrhythmogenic risk of ranolazine and quinidine, offering a potential tool for preclinical cardiac toxicity screening.
Costabal et al. (2018) studied this question.
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