Why the study?
Does the canine telemetry assay accurately detect drug-induced QT interval prolongation?
Population
Canine telemetry assay data from 12 studies in the QT PRODACT project
Design
Preclinical, 4x4 Latin square cross-over design
Authors
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May support canine telemetry for preclinical QT screening; leaves open human translation and regulatory adoption.
Does the canine telemetry assay accurately detect drug-induced QT interval prolongation?
The canine telemetry assay using an individual subject heart rate correction model with a 5% cutoff is a highly sensitive and specific system for in vivo assessment of QT prolongation risk.
Miyazaki et al. (2005) studied this question.
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