Population
Male beagle dogs (8-17 months old, 9.0-15.5 kg) anesthetized with isoflurane
Comparison
Intravenous cumulative infusion of 10 positive… vs Vehicle administration infused repeatedly
Design
Preclinical
Follow-up
30 minutes after the start of each infusion
Authors
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Animal data support dog model differentiation of torsadogens; leaves open translation to human TdP risk prediction.
The isoflurane-anesthetized dog model accurately differentiates between torsadogenic and non-torsadogenic pharmaceuticals, supporting its utility in preclinical QT interval prolongation screening.
Tashibu et al. (2005) studied this question.
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