Why the study?
Can the pharmacokinetic-pharmacodynamic relationship of drug-induced QTc prolongation in conscious dogs predict the pro-arrhythmic potential in humans?
Population
Conscious dogs and humans (data derived from clinical trials)
Design
Preclinical
Authors
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Species differences in QTc slope urge caution extrapolating dog data to humans; leaves open clinical validation of conscious dog models.
Can the pharmacokinetic-pharmacodynamic relationship of drug-induced QTc prolongation in conscious dogs predict the pro-arrhythmic potential in humans?
The slope of the pharmacokinetic-pharmacodynamic relationship in conscious dogs can be used to predict the risk of drug-induced QTc prolongation in humans.
Chain et al. (2013) studied this question.
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