Why the study?
Does the QTc prolonging effect of moxifloxacin and NCE05 differ quantitatively between cynomolgus monkeys, dogs, and humans?
Does the QTc prolonging effect of moxifloxacin and NCE05 differ quantitatively between cynomolgus monkeys, dogs, and humans?
Significant interspecies differences exist in the QT-prolonging effect of moxifloxacin, highlighting the need for translation functions to predict human concentration-effect relationships from animal models.
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Species differences in moxifloxacin QT sensitivity warrant caution extrapolating animal data to humans; leaves open validated translation functions for reliable predictions.
Dubois et al. (2015) studied this question.
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