October 1, 2003Assay and Drug Development Technologies

Flux Assays in High Throughput Screening of Ion Channels in Drug Discovery

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Population

Ion channels in drug discovery

Comparison

Flux assays for high throughput screening vs Patch clamp data

Design

Review

Authors

SGSikander GillBritish Columbia Centre on Substance Use RGRaj GillUniversity of Sussex SLSoo Sen LeeBC Cancer Agency

Discussion

Member takes

Implication

May accelerate high-throughput ion channel screening; leaves open prospective validation for cardiovascular drug development.

Structured PICO

Population

Ion channels in drug discovery

Intervention

Flux assays (radiolabeled or nonradiolabeled) for high throughput screening

Comparator

Patch clamp data

Outcome

Detection of functional ionic flux and accurate drug rank orderssurrogate

Flux assays, particularly nonradiolabeled rubidium-based assays, offer a high-throughput, automated alternative to patch clamping for ion channel drug discovery.

Cite This Study

Gill et al. (2003) studied this question.

synapsesocial.com/papers/6a708927f44fa9f079de333d https://doi.org/10.1089/154065803770381066

View Full Paper

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Flux Assays in High Throughput Screening of Ion Channels in Drug Discovery

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Flux Assays in High Throughput Screening of Ion Channels in Drug Discovery

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider