Why the study?
Do methohexital and pentobarbital inhibit inwardly rectifying K+ currents in RBL-1 cells?
Population
Rat basophilic granulocyte cell line (RBL-1)
Design
Preclinical
Authors
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Does not support clinical changes; leaves open whether Kir inhibition mediates barbiturate effects in vivo.
Do methohexital and pentobarbital inhibit inwardly rectifying K+ currents in RBL-1 cells?
Barbiturates such as methohexital and pentobarbital inhibit fast inwardly rectifying K+ channels, identifying a potential molecular target for their diverse clinical effects.
Gibbons et al. (1996) studied this question.
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