Why the study?
Do halothane and isoflurane modulate the inward rectifier K+ current in guinea pig ventricular myocytes?
Population
Guinea pig ventricular myocytes
Comparison
Halothane and isoflurane vs Control conditions
Design
Preclinical
Authors
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May link volatile anesthetics to dysrhythmias via IKir in guinea pig myocytes; leaves open human relevance and clinical translation.
Do halothane and isoflurane modulate the inward rectifier K+ current in guinea pig ventricular myocytes?
Volatile anesthetics halothane and isoflurane modulate the myocardial inward rectifier potassium current, which may contribute to the mechanism of their dysrhythmic actions.
Stadnicka et al. (2000) studied this question.
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