Why the study?
Do halothane and ketamine alter the activation and inactivation of myocardial calcium currents in ventricular myocytes?
Population
Single guinea pig ventricular myocytes
Comparison
Halothane (1%) and ketamine (10(-4) M) vs Baseline/control (unexposed state)
Design
Preclinical
Authors
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Caution against clinical extrapolation from animal myocytes; extends in vitro mechanistic insight but leaves human relevance open.
Do halothane and ketamine alter the activation and inactivation of myocardial calcium currents in ventricular myocytes?
Both halothane and ketamine produce parallel shifts in the activation and inactivation of calcium currents in normal ventricular myocytes, providing insight into their electrophysiological effects on the heart.
Baum et al. (1994) studied this question.
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