Why the study?
Do halothane and isoflurane affect calcium and potassium channel currents in canine coronary arterial cells?
Population
Single coronary arterial cells from canine coronary artery (n=45 for IK, n=39 for ICa)
Comparison
Halothane (0.75% and 1.5%) and isoflurane (2.6%) vs Baseline/control conditions without anesthetics
Design
Preclinical
Authors
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Should not alter anesthetic choice; leaves open whether preferential ICa reduction translates to human coronary vasomotion.
Do halothane and isoflurane affect calcium and potassium channel currents in canine coronary arterial cells?
Halothane and isoflurane suppress both potassium and calcium channel currents in canine coronary arterial cells, with a preferential reduction in calcium currents.
Buljubasíc et al. (1992) studied this question.
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