Why the study?
Do volatile anesthetics suppress L- and T-type calcium channel currents in canine cardiac Purkinje cells?
Population
Single canine cardiac Purkinje cells
Design
Preclinical
Authors
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Supports anesthetic effects on canine Purkinje calcium currents; leaves open human translation and clinical relevance.
Do volatile anesthetics suppress L- and T-type calcium channel currents in canine cardiac Purkinje cells?
Volatile anesthetics (halothane, isoflurane, enflurane) produce concentration-dependent suppression of both L- and T-type calcium channel currents in canine cardiac Purkinje cells.
Eskinder et al. (1991) studied this question.
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