August 1, 2001AnesthesiologyOpen Access

Differential Modulation of the Cardiac L- and T-type Calcium Channel Currents by Isoflurane

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Why the study?

Does isoflurane differentially modulate atrial and ventricular L- and T-type calcium channel currents in guinea pig cardiomyocytes?

Population

Enzymatically isolated guinea pig cardiomyocytes

Design

Preclinical

Authors

ACAmadou K.S. CamaraMedical College of Wisconsin ZBZeljana BegicNational Postdoctoral Association WKWai‐Meng KwokMedical College of Wisconsin

Discussion

Member takes

Implication

Should not change isoflurane use in patients; leaves open whether differential atrial-ventricular effects occur in humans.

Structured PICO

Does isoflurane differentially modulate atrial and ventricular L- and T-type calcium channel currents in guinea pig cardiomyocytes?

Population

Enzymatically isolated guinea pig cardiomyocytes

Intervention

Isoflurane (dose-dependent administration)

Outcome

Atrial L- and T-type calcium currents (I(Ca,L) and I(Ca,T)) and ventricular I(Ca,L)surrogate

Isoflurane depresses cardiac calcium currents with differential sensitivity, being most potent on atrial T-type channels and least on ventricular L-type channels.

Cite This Study

Camara et al. (2001) studied this question.

synapsesocial.com/papers/6a7272a4e5469ee92be26b15 https://doi.org/10.1097/00000542-200108000-00038

View Full Paper

Ask AI

Bookmark

Differential Modulation of the Cardiac L- and T-type Calcium Channel Currents by Isoflurane

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Differential Modulation of the Cardiac L- and T-type Calcium Channel Currents by Isoflurane

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider